Bioinformatician
Posted 29/04/2024 by Marketplace Technical
Exciting Medical Devices Development company seeks an experienced Bioinformatician.
About the role:
The Bioinformatician will work within the Assay Team to develop point of care molecular diagnostic assays and associated technologies. It is an opportunity for candidates with a strong background in sequence-based bioinformatics to contribute on projects leading to the development of diagnostic assays.
Duties may include:
- Work within the Assay Team to deliver molecular diagnostic product pipeline.
- Identify appropriate reference sources for sequences, for example public sources such as GISAID and NCBI databases.
- Familiar with NextGen sequencing and associated pipelines.
- Collate and annotate reference sequences across multiple microorganisms.
- Be confident using python and Jupyter Lab books as a working and application development environment along with GIT as a version control system.
- Generate, record, manipulate, analyse and present complex data to line manager, colleagues, senior management and external partners.
- Maintain records, logs and or databases of analyses for regulatory reporting purposes.
- Interrogate sequence data to design new diagnostic assays, applying assay team lead rules (e.g. Tm, primer length, GC ratio) to shortlist targets for experimental testing.
- Undertake in silico inclusivity and exclusivity testing and analyse homology to confirm target suitability.
- Undertake periodic in silico review of existing assay designs to confirm ongoing suitability of the assay for VOC, VUI and variants being monitored.
- Work on collaborative projects with external partners and be point of contact for bioinformatics.
- Work within the quality systems following GDP and ISO 13485 standards.
Skills and experience:
- MSc degree or equivalent in a relevant subject (i.e. bioinformatics, computer science or statistics).
- Relevant experience in bioinformatics with a strong knowledge of microbial genomics.
- Familiarity with sequencing data (Sanger and NGS) and standard bioinformatics tools (alignment, variant calling, assembly etc.)
- Experience in data manipulation and analysis of large genomic datasets.
- Knowledge and competence in Python, Docker, Git, Linux, MySQL or similar software development tool.
- Knowledge of nucleic acid amplification and detection chemistries.
- Ability to work to the Quality Management Systems in line with ISO13485 standards.
- Hands on experience with the manipulation and development of PCR chemistries for diagnostic tests.
- GPU programming.
- Eligible to work full time in the UK without restriction.
Apply now for more information
- Type:
- Permanent
- Contract Length:
- N/A
- Contact Name:
- Login or register to view
- Job Reference:
- MATECBB966_1714405253
- Job ID:
- 221558722
Remember: You should never send cash or cheques to a prospective employer, or provide any financial information. Please get in touch if you see any roles asking for payments or financial details from you. For more information, visit jobsaware.co.uk.